Cantharidin: An Active Compound of Blister Beetle Caused Mitochondrial Damage and Induced Apoptosis, Necrosis and Autophagy in Dalton’s Ascites Lymphoma in vivo
نویسندگان
چکیده
Prevention is undeniably the sensible maneuver towards the ultimate goal of cancer control [1]. According to the World Cancer Report released by the World Health Organization (WHO) in 2003 [2], cancer rates could further increase by 50% to 15 million new cases in the year 2020. Chemotherapy, radiotherapy and surgery are commonly used treatment methods for cancer in modern medicine. Chemotherapy is now considered as the most effective method of cancer treatment. However, most cancer chemotheraputants severely affect the host normal cells [3]. Hence, the use of natural products mainly plants and animals now have been contemplated of exceptional value in the control of cancer and its eradication program [1].
منابع مشابه
Antiproliferative activity and apoptosis inducing mechanism of Anthocephalus cadamba on Dalton’s lymphoma ascites cells
AbstractThe purpose of this investigation was to evaluate the antiproliferative and apoptogenic mechanistic studies of methanol extract of Anthocephalus cadamba (MEAC) on Dalton’s lymphoma ascites (DLA) cells treated mice. Determination of antiproliferative activity was performed by using different DLA cells (2×106 cells, i.p.) inoculated mice groups (n=12). Groups were treated for 14 consecuti...
متن کاملAntiproliferative activity and apoptosis inducing mechanism of Anthocephalus cadamba on Dalton’s lymphoma ascites cells
AbstractThe purpose of this investigation was to evaluate the antiproliferative and apoptogenic mechanistic studies of methanol extract of Anthocephalus cadamba (MEAC) on Dalton’s lymphoma ascites (DLA) cells treated mice. Determination of antiproliferative activity was performed by using different DLA cells (2×106 cells, i.p.) inoculated mice groups (n=12). Groups were treated for 14 consecuti...
متن کاملالقای آپوپتوز توسط کانتاریدین در پروماستیگوتها و ماکروفاژهای آلوده به آماستیگوتهای لیشمانیا ماژور در شرایط آزمایشگاهی
Background and purpose: Leishmania is flagellated protozoa and causative agent of leishmaniosis. It is one of the main public health problems in developing countries. Cantharidin is terpenoid component that exists in Meloidae and Oedemeridae beetles. Cantharidin is vesicant and could induce apoptosis in cancerous cells. This study was performed to determine the role of cantharidin in inducing a...
متن کاملAtg5 siRNA inhibits autophagy and enhances norcantharidin-induced apoptosis in hepatocellular carcinoma.
Cantharidin is a terpenoid isolated from Chinese blister beetles, and norcantharidin (NCTD) is a demethylated analog of cantharidin. It has been reported that cantharidin and norcantharidin have anticancer activities. Growing evidence suggests that inhibiting autophagy can induce apoptosis in the human hepatoma cell line HepG2. The objective of the present study was to determine whether inhibit...
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Oral cancer is a subtype of head and neck cancer which represents 2.65% of all human malignancies. Most of oral cancer is histopathologically diagnosed as oral squamous cell carcinoma (OSCC). OSCC is characterized by a high degree of local invasion and a high rate of metastasis to the cervical lymph nodes. How to prevention and treatment of OSCC is important and imperative. Here, we investigate...
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